My entire research career has been focused on the understanding of the genetic mechanisms underlying the way the brain functions in general and dysfunctions in disease. Currently, my interest is focused on finding genes associated with the variation of brain structure and function and use these genes as risk-conferring candidates for complex diseases.

My experience includes research on the genetic causes of Alzheimer's disease (AD), Parkinson's disease, stroke, Major depressive Disorder and currently, ADHD. In order to identify genes related to these complex diseases, I have applied the most up-to-date statistical-genetics techniques available. In 2006 I finished my PhD where I was able to identify new loci linked to AD, suggested the presence of new candidate genes and replicated previously associated candidate genes and linked loci for this disease. In 2007 I moved to the RUNMC and joined the Research lab for Multifactorial Diseases (PI Prof. Barbara Franke) at the Departments of Human Genetics, Psychiatry & Cognitive Neuroscience and have successfully performed multiple genetic epidemiology analysis searching for genetic variants involved in the genetic susceptibility for ADHD, MDD and brain structure. At this moment, I'm involved in the core group of the biggest brain imaging genetics consortium in the world, the ENIGMA consortium, from which our group is a founding member (http://enigma.loni.ucla.edu/). Further, I'm also involved in the development of methodology to proper test gene-gene interaction effects applying novel Bayesian based analysis techniques

Since February 2000 I work at the department of Human Genetics. At the Researchlab for Multifactorial Diseases within the department I am responsible for the supervision of technicians, I co-supervise students and support the management. I work as a project manager for the international IMpACT group. I am currently responsible for the development and coordination of the IMpACT website.

I am now a PhD in the Research lab ‘Multifactorial Diseases’ at the Department of Human Genetics, Radboudumc (supervisors Martine Hoogman & Alejandro Arias Vasquez). My contribution to the IMpACT 2 project during the next 3 years will consist in investigating the relationship between the gut microbiome and emotional dysregulation in ADHD. Although emotional dysregulation is not considered an intrinsic component of ADHD in the DSM-5 , literature on ADHD demonstrates that problems in emotional regulation are frequent and strongly affect the quality of life. Moreover, brain regions involved in emotion processing show structural and functional alterations in ADHD. Since the gut-brain axis links the centers for emotional processing to the gut, the microbiota hosted here could represent one of the environmental factors (partly) responsible for emotional dysregulation in ADHD. To test this hypothesis, I will combine neuroimaging techniques with microbial taxonomic analysis.

I am Lisa Horstman and I am currently working as a research assistant on the IMPaCT project. My specific tasks are setting up and managing the now online IMPaCT light study. I gained a masters in Neuropsychology at the University of Maastricht and I am very interested in the brain-behavior relationship in different clinical settings.

I studied medical biology at the Radboud University of Nijmegen and became especially interested in neurobiology and imaging genetics. In 2013 I started my PhD project in the group of Barbara Franke. Because we still know very little about the genes and genetic variants underlying the development of ADHD, I first aim to identify novel genes for ADHD by combining linkage analysis and whole exome sequencing in large ADHD families. Second, I want to investigate how the brain is affected by genes causing ADHD and how alterations of brain structure and function by such genes contribute to the cognitive deficits and symptoms observed in ADHD. To study the link between genes and brain structure and function, and the behavior of adult ADHD patients and healthy individuals, I combine advanced genetics with the analysis of neuroimaging data (both functional and structural MRI).

I am Martine Hoogman and I’m currently working as an assistant professor at the department of Psychiatry and Human Genetics of the Radboud University Medical Center in Nijmegen the Netherlands. I have my own research group which focuses on the positive aspects, strengths and resilience associated with ADHD and ASD. I have been involved in the IMPACT1-NL, IMpACT2-NL and now IMpACT2light-NL studies. These studies were/are aimed at unraveling ADHD in adults by using multidimensional data (imaging, genetics, cognition, behavior, microbiome etc). Please seehttps://martinehoogman.com for more information.